@article {3093014,
	title = {Onset, duration and unresolved symptoms, including smell and taste changes, in mild COVID-19 infection: a cohort study in Israeli patients},
	journal = {Clin Microbiol Infect},
	volume = {27},
	number = {5},
	year = {2021},
	note = {1469-0691Klein, HadarAsseo, KimKarni, NoamBenjamini, YuvalNir-Paz, RanMuszkat, MordechaiIsrael, SarahNiv, Masha YJournal Article2021/02/20Clin Microbiol Infect. 2021 Feb 16;27(5):769-74. doi: 10.1016/j.cmi.2021.02.008.},
	month = {Feb 16},
	pages = {769-74},
	edition = {20210216},
	abstract = {OBJECTIVES: To characterize longitudinal symptoms of mild coronavirus disease 2019 (COVID-19) patients for a period of 6~months, to potentially aid in disease management. METHODS: Phone interviews were conducted with 103 patients with mild COVID-19 in Israel over a 6-month period (April 2020 to October 2020). Patients were recruited via social media and word to mouth and were interviewed up to 4 times, depending on reports of their unresolved symptoms. Inclusion criteria required participants to be residents of Israel aged 18~years or older, with positive COVID-19 real-time PCR results and nonsevere symptoms. The onset, duration, severity and resolution of symptoms were analysed. RESULTS: A total of 44\% (45/103), 41\% (42/103), 39\% (40/103) and 38\% (39/103) of patients experienced headache, fever, muscle ache and dry cough as the first symptom respectively. Smell and taste changes were experienced at 3.9~{\textpm}~5.4 and 4.6~{\textpm}~5.7~days (mean~{\textpm}~standard deviation (SD)) after disease onset respectively. Among prevalent symptoms, fever had the shortest duration (5.8~{\textpm}~8.6~days), and taste and smell changes were the longest-lasting symptoms (17.2~{\textpm}~17.6 and 18.9~{\textpm}~19.7~days; durations censored at 60~days). Longer recovery of the sense of smell correlated with the extent of smell change. At the 6-month follow-up, 46\% (47/103) of the patients had at least one unresolved symptom, most commonly fatigue (22\%, 23/103), smell and taste changes (15\%, 15/103 and 8\%, 8/103 respectively) and breathing difficulties (8\%, 8/103). CONCLUSIONS: Long-lasting effects of mild COVID-19 manifested in almost half of the participants reporting at least one unresolved symptom after 6~months.},
	keywords = {COVID-19, Disease course, Recovery, Smell change, Symptoms duration, Taste change, Unresolved symptoms},
	isbn = {1198-743X (Print)1198-743x},
	author = {Klein, H. and Asseo, K. and Karni, N. and Benjamini, Y. and Nir-Paz, R. and Muszkat, M. and Israel, S. and Niv, M.Y.}
}
