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Resting mononuclear cell NR3C1 and SKA2 expression levels predict blunted cortisol reactivity to combat training stress among elite army cadets exposed to childhood adversity | Faculty of Social Sciences

Resting mononuclear cell NR3C1 and SKA2 expression levels predict blunted cortisol reactivity to combat training stress among elite army cadets exposed to childhood adversity

Citation:

Carmel Kalla, Goltser-Dubner, Tanya , Pevzner, Dalya , Canetti, Laura , Mirman, Aron , Ben-Yehuda, Ariel , Itzhar, Noa , Benarroch, Fortu , Shalev, Amit , Giesser, Ruth , Fruchter, Eyal , Vashdi, Inon , Oz, Osnat , Haber, Roni , Saloner, Chen , Lotan, Amit , Galili-Weisstub, Esti , Bonne, Omer , and Segman, Ronen . 2021. “Resting Mononuclear Cell Nr3C1 And Ska2 Expression Levels Predict Blunted Cortisol Reactivity To Combat Training Stress Among Elite Army Cadets Exposed To Childhood Adversity”. Molecular Psychiatry, 26, Pp. 6680-6687.

Abstract:

Childhood adversity (CA) may alter reactivity to stress throughout life, increasing risk for psychiatric and medical morbidity, yet long-term correlates of milder CA levels among high functioning healthy adolescents are less studied. The current study examined the prevalence and impact of CA exposure among a cohort of healthy motivated elite parachute unit volunteers, prospectively assessed at rest and at the height of an intensive combat-simulation exposure. We found significantly reduced gene expression levels in resting mononuclear cell nuclear receptor, subfamily 3, member 1 (NR3C1), and its transactivator spindle and kinetochore-associated protein 2 (SKA2), that predict blunted cortisol reactivity to combat-simulation stress among CA exposed adolescents. Long-term alterations in endocrine immune indices, subjective distress, and executive functions persist among healthy high functioning adolescents following milder CA exposure, and may promote resilience or vulnerability to later real-life combat exposure.